2026-02-19 01:38:37
2. Richard Ngo on educational signaling theories.
3. “There is no secular alternative. There has never been one.”
5. Dominicans vs. Franciscans.
7. Is Europe’s problem labor law?
8. Arbitrage in Singaporean aunties? The country is getting more interesting again.
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2026-02-18 20:17:57
Senator Bill Cassidy (R-La.) released a new report on how to modernize the FDA. It has some good material.
… FDA’s process for reviewing new products can be an unpredictable “black box.” FDA teams can differ greatly in the extent to which they require testing or impose standards that are not calibrated to the relevant risks. The perceived disconnect between the forward leaning rhetoric and thought leadership of senior FDA officials and cautious reviewer practice creates further unpredictability. This uncertainty dampens investment and increases the time it takes for patients to receive new therapies.
Companies report that they face a “reviewer lottery,” where critical questions hinge on the approach of a small number of individuals at FDA. Some FDA review teams are creative and forward-leaning, helping developers design programs and overcome obstacles to get needed products to patients, without cutting corners. FDA’s Oncology Center of Excellence (OCE), for example, is repeatedly identified as a model for providing predictable yet flexible options for bringing new drugs to cancer patients. OCE is now a dialogue-based regulatory paradigm that has facilitated efforts by academia, industry, the National Institutes of Health (NIH), and others to develop new cancer therapies and launch innovative programs and pilots like Project Orbis, RealTime Oncology Review.
That’s quite right. In my report with DiMasi and Milne, we show that review times vary markedly within the FDA, across divisions, without clear cause. Put aside the big questions of FDA or no FDA–scaling the practices of the better-performing divisions would likely yield large gains.
Mike Doherty further asks the AI what Alex Tabarrok would think of the Cassidy report. It replies:
Strongest features: It correctly diagnoses FDA as a bottleneck to innovation, emphasizes “least burdensome” evidence, calls for streamlined pathways (505(b)(2)-style for biologics, biosimilar simplification), and worries about U.S. losing early-phase trials to other countries. This is very much in Tabarrok’s wheelhouse: regulation as a hidden tax on innovation and growth.
Weakest features: It rarely quantifies tradeoffs, almost never confronts the “invisible graveyard” of patients who never see therapies because of delay, and treats reforms as marginal tweaks rather than testing fundamentally different regulatory models (e.g., insurance-based approval, private certification, or sunset/experimentation with parallel regimes).
If you imagine this as a draft memo handed to Tabarrok, he’d likely say: “Good directionally; now add 50% more economics, 50% more quantification, and 100% more willingness to experiment with institutional competition.”
Yeah, pretty good.
Addendum: In other FDA news see also Adam Kroetsch on Will Bayesian Statistics Transform Trials?
Addendum 2: FDA has now agreed to review Moderna’s flu vaccine which is good although the course reversal obviously speaks to the unpredictability of the FDA.
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2026-02-18 15:28:22
I suggest looking at whether real estate prices in a particular locale have been rising or falling. If immigration is “ruining” a particular city, we would expect homes and other property values in that place to become much cheaper.
Home values have historically served as a strong indicator of the health of a city. Consider Detroit. It was one of the premier American cities in the mid-20th century, but the region lost a lot of its automobile industry to foreign competition, and crime rose precipitously. The city also was poorly managed. The result in real estate markets was a collapse in prices. If anyone asked you to point to quantifiable evidence for the decline in Detroit, it was easy to do so.
Detroit has undergone a renaissance since its nadir. New businesses have opened, crime rates have fallen, and the city feels more lively again. And since that turn of fortune, often dated around the 1990s, Detroit real estate has made a major comeback, putting aside the price collapse of the Great Recession in 2008. Home prices are not a perfect measure of how the city is doing, but they do pick up major and radical trends, both on the downside and on the upside.
The nice thing about market prices is that they show how buyers weigh the benefits of immigration against costs. Say some new immigrants have moved into your community and the quality of the schools has declined somewhat and traffic is modestly worse. At the same time, there are new businesses, the streets feel more lively, and it is easier to get a good local plumber. In the abstract, it is hard to tell which effects might be most important. But individuals, when bidding for homes or deciding to sell, make their own judgments. What happens to the home prices is a reflection of the collective judgments of people with major decisions about their lives on the line.
Of course in most of the Western world, including Malmo, real estate prices are healthy and very often rising. Here is the full Free Press link, by yours truly. The piece of course does cover the usual caveats, such as bubbles and busts, but note NIMBY factors will not alone reverse the basic conclusions.
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2026-02-18 14:06:16
Can AI be liberal? In what sense? One answer points to the liberal insistence on freedom of choice, understood as a product of the commitment to personal autonomy and individual dignity. Mill and Hayek are of course defining figures here, emphasizing the epistemic foundations for freedom of choice. “Choice Engines,” powered by AI and authorized or required by law, might promote liberal goals (and in the process, produce significant increases in human welfare). A key reason is that they can simultaneously (1) preserve autonomy, (2) respect dignity, and (3) help people to overcome inadequate information and behavioral biases, which can produce internalities, understood as costs that people impose on their future selves, and also externalities, understood as costs that people impose on others. Different consumers care about different things, of course, which is a reason to insist on a high degree of freedom of choice, even in the presence of internalities and externalities. AI-powered Choice Engines can respect that freedom, not least through personalization. Nonetheless, AI-powered Choice Engines might be enlisted by insufficiently informed or self-interested actors, who might exploit inadequate information or behavioral biases, and thus co5mpromise liberal goals. AI-powered Choice Engines might also be deceptive or manipulative, again compromising liberal goals, and legal safeguards are necessary to reduce the relevant risks. Illiberal or antiliberal AI is not merely imaginable; it is in place. Still, liberal AI is not an oxymoron. It could make life less nasty, less brutish, less short, and less hard – and more free.
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2026-02-18 03:14:40
From a recent paper by Sebastian Galiani and Raul A. Sosa:
Fertility rates have fallen below replacement in most countries, fueling predictions of demographic collapse. We show these forecasts overlook a crucial fact: societies are not homogeneous. Using the Bisin–Verdier model of cultural transmission with endogenous fertility and direct socialization, calibrated to U.S. and global data, we find that high-fertility, high-retention groups persist, gain share, and lead the total population to grow. Even if fertility remains below replacement in every country, extinction is unlikely. Simulations imply continued growth with pronounced compositional change, driven especially by religious communities with high fertility. In our ten-generation world calibration, Muslims become the largest tradition.
I am pleased to hear that extinction is unlikely.
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2026-02-18 00:56:24
1. The separating equilibrium.
2. Can speed revitalize American manufacturing?
3, Malmo real estate prices are doing fine.
4. AI and economics summer institute at University of Chicago.
5. Why total legal services costs may not fall with AI. Correct working link here.
6. Sylvia Plath in her journals.
7. Stephen Kinsella Substack on the economy of Ireland.
p.s. hbsk!
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