2026-10-08 18:00:00
This week, we released our 2026 version of our Climate Tech Companies to Watch list. It’s an annual project that the MIT Technology Review team puts together. Our goal is to highlight some of the promising, interesting advances and firms we think are worth paying attention to in the world of climate and energy technology.
The list is always a little ray of hope for me—there are some fascinating ideas out there for changing how we power our world or moving away from fossil fuels to reduce the greenhouse-gas emissions that cause climate change.
Our chosen companies tend to reflect several aspects of the current moment. Here are some of the companies we picked and the key themes worth highlighting.
Forgive me—I know I’ve made this point before. Feel free to call me Captain Obvious. But I think China’s dominance in energy technology is a global trend that bears repeated mentioning.
China is home to the world’s largest grid, and renewables are coming online more quickly than I can wrap my head around. Contributing to that boom is Envision Energy, a renewables giant appearing on our list for the second time. The company has installed over 100 gigawatts of wind power worldwide, as well as over 50 gigawatt-hours of battery storage.
Like many other Chinese companies right now, Envision is looking beyond the crowded Chinese market and setting its sights abroad, with projects in Germany, Brazil, and Australia and upcoming work in Vietnam.
China is also leading innovation in key technologies. I’ve been fascinated by the potential for next-generation batteries coming out of its companies: All the big ones, along with a host of smaller ones, are racing to develop solid-state batteries. They could be both safer than existing EV batteries and longer in range.
WeLion New Energy is particularly interesting. The battery company announced a big lab result last year, achieving 824 watt-hours per kilogram—more than three times the energy density of a standard lithium-ion battery today. Lab results in battery research are notoriously difficult to scale, but WeLion is also working to deploy semi-solid-state batteries, which could come to fruition faster than purely solid-state cells while still improving on lithium-ion’s performance.
We included just three companies from the US on the list, and two of them have received a major boost from Big Tech as companies look to power data centers. (The third, Brimstone, is leaning into another political hot topic, critical minerals.) Technologies that can provide consistent power are in high demand.
Fervo Energy is bringing next-generation geothermal power to the grid by using horizontal drilling and hydraulic fracturing to make it practical in more places. The company went public in May, raising $2.2 billion in its IPO, and plans to have a gigawatt’s worth of plants operational by the end of 2030.
X-energy is building helium-cooled small modular nuclear reactors. The reactors’ small size lends flexibility, and the company is currently working on a 320-megawatt cluster of them in collaboration with Amazon in Richland, Washington. (For what it’s worth, I’m interested in what this technology could do for industrial facilities—the company has a deal with Dow that could see it deployed at one of the company’s chemical plants in the early 2030s.)
I know, I know—I haven’t stopped talking about batteries since I started writing this newsletter four years ago. But the energy storage market has surpassed even my expectations over that time. And as solar and wind quickly come online, they need storage to help them meet more of the grid’s demand.
Form Energy is on the list for a third time for its iron-air batteries, which could enable cheaper long-duration energy storage. The company has a massive project in the works, to the tune of 30 gigawatt-hours, which will be used to help power a Google data center. It could be the world’s largest battery project in terms of capacity by the time it comes online, which is expected to happen in phases between 2028 and 2031.
Taking another tack, Energy Dome is using compressed carbon dioxide to store energy on the grid. This technology is already cheaper than lithium-ion batteries for longer durations (think 10 hours or more), and the company is working to scale quickly. I covered the company in 2022, before it had its first commercial plant running. Now it has plans for over 30 gigawatt-hours’ worth of plants around the world, including one with Google in Ireland that’s slated to come online in 2028.
And Moment Energy is working to use the million EV batteries that are expected to reach the end of their life by 2030. The company has a facility in Vancouver, British Columbia, that repurposes used batteries for backup power.
This year hasn’t been all sunshine and rainbows for climate tech. But I’m hopeful that some of the companies on this list, and the technologies they build, will keep nudging us in the right direction.
This article is from The Spark, MIT Technology Review’s weekly climate newsletter. To receive it in your inbox every Wednesday, sign up here.
2026-10-08 17:00:00
The story is a collaboration between MIT Technology Review and Aventine, a non-profit research foundation that creates and supports content about how technology and science are changing the way we live.
A robot shaped like a human—white with a black head and torso—has been popping up on video feeds. Perhaps you’ve seen it dance or pass popcorn, put trash in a bin, vacuum, or press the button of a microwave. Or maybe you’ve watched it fall backward while handing out water bottles or struggle to iron a shirt.
This would be Tesla’s Optimus, an AI-powered humanoid robot that Elon Musk, the company’s CEO, believes will be “not just Tesla’s biggest product ever, but probably the biggest product ever,” headed to work on factory floors and, later, in our homes. Eventually it “will have human and then superhuman dexterity,” he told shareholders in July. Optimus robots could automate almost all human labor—from hauling sheet metal to folding laundry—for as little as $20,000 each, Musk argues. Speaking at the World Economic Forum’s annual meeting in Davos, Switzerland, in January, he predicted they could be on sale to the public by the end of 2027.
Musk is not alone in his evangelism. Marc Andreessen, cofounder and general partner of the Silicon Valley venture capital firm Andreessen Horowitz, has said that robotics could become the “biggest industry in the history of the planet.” In January, Jensen Huang, CEO of Nvidia, said that humanoid robots would match human-level ability this year. According to Morgan Stanley, the number of robots that “resemble and act like humans” is likely to reach nearly 1 billion by 2050, creating a market worth over $5 trillion.
Such proclamations are in large part fueled by the idea that the same AI advances behind tools like OpenAI’s ChatGPT and Anthropic’s Claude will enable a new generation of robots to imitate human movement the way chatbots imitate human language. But many robotics researchers are skeptical, arguing that such assumptions minimize the challenges of using an intelligence built on language and images to master the infinite variability of the physical world. “None of those companies [building humanoid robots]—absolutely none of them—has any idea how to make those robots smart enough to be useful,” Yann LeCun, often referred to as one of the godfathers of AI, said at another event during the January Davos conference.
Researchers also point out that the tendency to conflate humanoid robots made to resemble people with so-called generalist machines able to learn and perform multiple tasks is misleading. ”It’s very easy to make a robot that looks like a person,” explains Jonathan Hurst, cofounder and chief robot officer of Agility Robotics and professor of robotics at Oregon State University. “It is dramatically more difficult to make a machine that moves or behaves dynamically or physically like a person.”
These tensions—over whether all-purpose humanoid robots are just around the corner or nowhere in sight, and whether current forms of AI are all that’s needed to perfect them—are playing out in robotics labs across the country, where the hype over timelines is obscuring painstaking but meaningful progress.
A decade or so ago, a series of breakthroughs led to a generative AI revolution that turned the long-imagined possibility of artificial intelligence into reality. Roboticists—though they disagree on exactly when this will happen—believe that an equally transformative revolution is possible in robotics, one that will endow machines with physical intuition and fluidity that has long been out of reach. As progress in robotics inches forward, the question is whether the same methods and tools that fueled advances in AI are enough to get there, or if an entirely new path is required.
To see one of the smartest robot brains working today, it’s worth looking at what Google DeepMind can do with a piece of equipment called ALOHA 2, short for “A Low-cost Open-source Hardware System for Bimanual Teleoperation.”
Roboticists have long clashed over whether a humanlike form is necessary for generalist robots, with proponents arguing that it will help them slot into the world as it exists and detractors saying it’s not worth the trouble. ALOHA 2 reflects this second way of thinking. Not much to look at, it’s just a pair of arms, some grippers, and a couple of cameras. But despite its seeming simplicity, it is a workhorse for researchers at Google DeepMind, who use it to test their most advanced AI for robotics system, Gemini Robotics, in their various labs.
When controlled by Gemini Robotics, ALOHA 2 becomes more of a generalist robot, in the sense that it can perform any number of tasks based on examples it’s been trained on. Ask it to pack a lunchbox and, as evidenced by a video of this exercise, it can use two pincer grippers to delicately place a piece of white bread into a Ziploc bag, close it, place a bunch of grapes in a Tupperware container, secure the lid, and then carefully move the items into a lunchbox before zipping it up.
It’s not a great lunch. But the fact that the robot can put it together represents an objective step forward from what was possible even, say, three years ago.
This is in large part due to AI and its impact on what are known as robot policies, which controls how a general-purpose robot will need to assess and understand its surroundings, plan how to move within them, and then perform its task correctly.
The ALOHA 2 robot isn’t much more than two mechanical arms on a bench top, but it serves as a testbed for cutting-edge AI robotics models. These animations are based on human teleoperation of the robot arms, data that is used to train Google DeepMind’s models. (Video: Google DeepMind / Stanford University / Hoku Labs)
Historically, these policies were based on rules developed by engineers who hard-coded them into the robot’s software—thousands of lines of code that would determine each millimeter of a robot’s movements in hundreds of tasks. What’s been happening for the last few years—and what is largely responsible for the optimism about generalist robots—is that robot policies are being handed over to advanced AI systems instead of being coded into the robot’s software. This first happened with VLMs, or vision-language models. These are similar to large language models, but they’re trained on images as well as words. Show a VLM a picture of a coffee spill and ask it to find a tool to clean up the mess, and it can identify a nearby cloth. This sort of immediate contextual understanding didn’t exist a couple of years ago when robot policies were hard-coded.
Next came vision-language-action models, which enable robots to assess their environment and take action within it. The models do this by adding yet another component: motion commands. VLAs are trained on a series of images or videos related to performing a given task along with associated data about how a robot arm moves to perform it. That movement data is typically collected through teleoperation, in which a human uses remote controls to lead a robot through an action. This sort of training allows the AI to learn how to command the robot to move and operate during a given task. Place a VLA-powered robot in front of a desk and tell it to “close a laptop” or “wrap up the headphone wire,” and it will survey the scene, identify the relevant object, plan a way to execute the request, and then swing its arms into action—at least if it has seen this task accomplished before.
The Gemini Robotics model is a VLA, trained on many hours of human demonstrations depicting a vast array of different actions. As a result, it can perform relatively complex tasks like picking up snow peas with kitchen tongs, doing origami, or putting together a simple lunch. It’s impressive, but there’s a glaring limitation: For now, if a robot controlled by a VLA is asked to perform a task that falls outside its training set, it’s highly likely to fail.
“Thinking about the space of all tasks, a real generalist policy would be able to do everything along that spectrum,” says Edward Johns, a robotics professor at Imperial College London. Today, though, a Gemini Robotics model can do only “a few things here and a few things there.”
So how do we get robots to be able to do more things? The usual answer is probably not surprising: Train them on more data.
More data, the thinking goes, equals more examples, and more examples equals more generality. Google DeepMind, for instance, wants to pull together “as much data as possible,” says Pannag Sanketi, a former tech lead in robotics at the company who’s currently working on his own AI robotics project. But where to get it? Large language models had the benefit of oceans of existing text for training. There is no corresponding pool of high-quality physical demonstrations on which to train robots. Researchers have a few ways to make up for this, but all have flaws. One is to employ large numbers of people to create and collect teleoperation data (costly and time-consuming). Another is to train VLAs on videos of people performing activities (the resulting data quality is poor). Yet another is to deploy robots in the real world and use data collected from those experiences to further refine AI models (robots aren’t safe or reliable outside labs). Sanketi thinks a “multi-prong” approach that uses data collected from all these sources is the most likely path forward.
But the belief that training data alone is the answer is far from universal. Agility’s Hurst describes it as “a fundamentally flawed premise.”
The issue is that tasks in the real world quickly explode in complexity. If you’re trying to, say, make coffee, there are myriad variables: No two kitchens are identical; coffee machines work in different ways; different cups require different grips; coffee grounds, hot water, and milk all need to be handled differently. Even this simple task requires understanding an ever-changing menu of possibilities. Achieving generality through VLAs, Hurst argues, would require “complete data coverage of all of the things that [a robot] could ever do.” Or, in other words, an almost infinite pool of training data.
LeCun is dismissive of the whole approach. “The [AI] approaches that have been successful for language do not work for high-dimensional, continuous, noisy data”—the kind of data that is commonplace in robotics, he said in Davos. “You have to use something else.”
The leading contender for “something else” is the so-called world model—a form of AI trained less on text than on a combination of video, three-dimensional scans, and sensor data and built to predict the outcomes of actions in the real world. The aim is to build models that possess an internal representation of reality precise enough to capture how the physical world actually operates—how objects move, collide, fall, and deform. If roboticists could train machines in simulations faithful enough to real-world physics, development would become faster, cheaper, and safer, reducing the need for real-world testing. Even more transformative, robots equipped with world models could reason about their surroundings rather than merely reacting to them, helping them anticipate the consequences of an action before taking it.
Companies like Nvidia and Google are working on the technology, and investor cash is pouring into high-profile startups. World Labs, cofounded by the Stanford AI researcher Fei-Fei Li, raised $1 billion in funding in February and was acquired by AMD at the end of September for $8.2 billion. AMI Labs, cofounded by LeCun (formerly Meta’s chief AI scientist), also raised $1 billion in March. Yet by their own admission, it is still early days. Late last year Li described the field as “nascent,” adding that “foundational approaches are still being established.” In a June Substack she described daunting challenges. For now, world models are a promising area of research rather than an immediate route to general-purpose robotics, but we are beginning to see glimmers of what they could achieve.
One such glimpse came with a small but potentially significant leap forward that took place in a San Francisco robotics lab last April.
In the heart of San Francisco’s Mission District, the startup Physical Intelligence—or PI (as in π), as it likes to be known—is focused on developing a universal brain that could, theoretically, turn any robot into a generalist. Using an everything-including-the-kitchen sink approach to training AI models for robots, the company recently observed a hint of what a robotic brain equipped with a world model could be capable of.
In 2024, PI published details of its first generalist robotics system, called π0, a VLA it claimed was the “most capable and dexterous generalist robot policy to date.” The model was initially trained on a 10,000-hour proprietary collection of human demonstrations gathered through teleoperation as well as several open-source robot datasets. A version released in spring 2025, π0.5, was trained on a wider variety of datasets, including labeled images from the web, lending it more versatility. A fall 2025 update, π0.6, added reinforcement learning to the model.
Each update yielded important improvements to the model’s performance, increasing its menu of abilities from slowly folding laundry to putting things away in new environments to completing tasks like folding boxes with a higher success rate. Then, in April 2026, π0.7 seemed to catapult PI into new territory. This version makes use of a less powerful world model that generates images of steps necessary to perform a task. As the robot undertakes the job, this “lightweight” model feeds it snapshots of what to do next.
The company claims that the model exhibits the first signs of compositional generalization, a term for AI systems’ ability to perform skills they’ve never been exposed to by recombining ones learned in their training data. One test involved asking a model to “load a sweet potato into the air fryer”—a task it had never previously encountered. In a demonstration video, the machine futzes around a little, makes a few false starts, and eventually manages a reasonable effort, though it doesn’t finish the task completely.
Sergey Levine, a professor at the University of California, Berkeley, and a cofounder of PI, is excited by the potential: “It’s actually the first time that we’ve convincingly seen that kind of compositional generalization, where we can basically ask the model to do tasks that we did not specifically collect data for and train it to do, and it’ll actually make a passable attempt.”
The success led the team to wonder how the model was able to achieve such a feat. After some digging, they found snippets of relevant labeled teleoperation data lurking in the training material, including two examples of a human controller using the robot to push an air fryer basket into the fryer. Those shreds of data might have been enough to enable π0.7 to almost air-fry a sweet potato.
For now, it remains unclear just how impressive π0.7’s abilities to generalize are. Still, given how fleeting the model’s exposure to air fryers had been, it offers a glimpse into how far cutting-edge research can currently take robots.
You might be sensing a disconnect between the halting baby steps robots are making in labs—“Look! It put a sweet potato into an air fryer!”—and the dazzling, lifelike nimbleness on view during many demonstrations and videos, where robots are seen doing everything from dancing on a stage to courteously serving drinks. Such demos often don’t clearly reveal a key fact: In many instances, humans are controlling the robot or have carefully scripted its actions. (The robot that appeared onstage with Nvidia CEO Jensen Huang in March 2025, for example, seemingly responding to his instructions and following him around, was remote-controlled by what its makers called “a puppeteer behind the scenes.”)
For now, fully autonomous motion planning so that a robot knows where it should go—especially in new, chaotic environments like a construction site or a unfamiliar home—remains a largely unsolved challenge. A bigger challenge still—albeit one that is often related—lies in getting robots to tackle larger, more ambiguous jobs that include multiple tasks and require decisions about how and in what order they’re done. This would be the difference between a robot that can put a plate into a microwave and one that can successfully respond to the prompt “Make dinner” by exploring the refrigerator, chopping ingredients, and firing up the stove. Google DeepMind’s best attempts at something like this—which involved asking its robot to survey a kitchen and pack all the ingredients for a mushroom risotto into a basket—have so far resulted in failure.
Adding to the challenge, a practical robot must essentially get it right every time. With VLAs, “people are very excited when their result goes from 50% success to 70% success,” says Marc Raibert, founder of Boston Dynamics. “But 70% success is like it doesn’t work, right?”
The few humanoids that are being tested in real-life settings are undertaking extremely limited tasks in tightly controlled environments. They’re far from generalists. Agility has hundreds of robots deployed across trials in facilities owned by GXO Logistics, Amazon, and Schaeffler, according to the company. But for now, Hurst says, the robots are targeting simple tasks such as moving bins and totes around. Even then, he adds, it took years to develop robots safe enough for logistics firms to even contemplate using them. For his part, Elon Musk claimed in May 2025 that “thousands” of his Optimus robots would be working at Tesla factories by the end of the year, but in January of this year he said that the company had only “some of the Tesla Optimus robots doing simple tasks in the factory.”
While humanoids are starting to venture onto the factory floor, making the jump to households will be even more difficult. Right now, should you so desire, you can preorder the 1X Neo home robot, expected to be ready for delivery sometime later this year. Yours for $20,000, it promises to take on “the boring and mundane tasks around the house”—putting away dishes, answering the door, tidying the living room—“so you can focus on what matters to you.” The idea is for this five-foot-six-inch robot to one day perform all those tasks autonomously, but for now a remote human operator is needed for it to do most things. (Yes, a person would need permission to peer into your home through the robot’s cameras.) Asked how long it will be until fully autonomous robots are ready for domestic work, Hurst said, “If I had to pick a number, I’d say it’s 10 years before robots are … actually doing useful things in people’s homes.”
When that happens, the robots might well be Chinese, as China is well ahead of the West in terms of production. Nearly 90% of the roughly 15,000 humanoid robots shipped in 2025 were made by Chinese companies, according to the market intelligence company Omdia and the Chinese robotics firm Unitree. One model produced by Unitree, which shipped more humanoid robots than any other company last year, costs less than $6,000. Such an affordable price could go a long way toward making robots more attractive to consumers, though the company expects its machines to be used in industrial applications first. (If you’re wondering who is buying all these Chinese robots, by the way, the AP recently reported that orders come predominantly from corporate and academic labs and state-owned enterprises.)
The dream of building a humanoid robot runs deep: As far back as 1495, Leonardo da Vinci sketched out designs for a mechanical knight, controlled by cables and pulleys. Through the 20th century, machines of sci-fi fever dreams have come and gone.
Westinghouse’s seven-foot-tall box on legs, Elektro, hit the New York World’s Fair in 1939, smoking a cigarette. WABOT-1, built by Waseda University in Japan in 1973, was the first full-scale, programmable humanoid robot. Honda’s ASIMO, unveiled in 2000, was probably the first such machine to prove at all competent—it could, at least to some degree, climb steps, recognize faces, and autonomously move through spaces. But the robot was discontinued in 2018, unable to advance far enough beyond what it could do in demonstrations to be useful.
All, at the time, were impressive—even jaw-dropping—feats of engineering. But none were ready to navigate the real world. Today’s robots, even with the transformative power of advanced AI, still face the same existential challenge.
2026-10-08 16:17:32
Industrial AI is entering a new phase. After decades of predictive analytics and other specialized applications, advances in foundation models, physical AI, and agentic AI are making it possible to automate more complex tasks across industrial environments. But unlike AI that operates purely in the digital world, industrial AI can interact directly with physical systems, where an unexpected decision can have consequences for safety, reliability, and critical infrastructure.
That makes responsible deployment central to the next wave of industrial automation. “How do we leverage these technologies while maintaining safety, while maintaining reliable operations, while still being able to deliver on the promises of the new capabilities?” asks Arti Garg, chief technologist at AVEVA. The challenge is particularly acute as newer AI systems become more capable but also harder to predict and explain.
One foundation for making that transition work is data. Industrial systems often contain information across telemetry, service logs, engineering documents, and other disparate sources. Newer technologies can help connect and correlate that information more quickly, giving operators real-time support when diagnosing problems. AI-powered robots could take that a step further by gathering information in hazardous environments without requiring workers to enter them.
But greater autonomy also requires new approaches to governance. AVEVA’s framework for responsible AI emphasizes security, efficiency, and human safety and oversight. Garg argues that AI should augment rather than replace people in critical decision loops, with guardrails determining where automated systems can act and where human supervisors remain responsible.
Sustainability is another part of that equation. AI can help manage complex power systems as renewable generation grows, while organizations also need better ways to understand AI’s own environmental footprint. Garg is involved in an IEEE working group developing a standard methodology for measuring that impact across electricity, energy, resources, water, and carbon.
The next phase could bring industrial AI further into the physical world, from autonomous robots and drones to AI-assisted coding that allows domain experts to build new applications. But realizing that potential will require more than deploying new technology, says Garg. Organizations will need to rethink business processes, establish appropriate safeguards, and give experienced workers new ways to apply their expertise, creating a model of automation that is not only more autonomous, but safer, more efficient, and more sustainable.
“Autonomous systems, whether they’re robots or drones, are really going to change the way that we work in plants, in power systems, on mining sites,” says Garg. “In a way, that will make these types of operations more efficient, much safer for the human beings involved and more productive.”
This episode of Business Lab is produced in partnership with AVEVA.
Full Transcript
Megan Tatum: From MIT Technology Review, I’m Megan Tatum, and this is Business Lab, the show that helps business leaders make sense of new technologies coming out of the lab and into the marketplace.
Industrial AI may not be new, but it is developing at a breakneck pace. From modern predictive analytics that can preempt equipment failures, to autonomous robots tasked with inspecting high risk machinery, emerging applications have the potential to transform operational efficiencies. But often used in high consequence environments with minimal margin for error, industrial AI deployed without clarity, security, or accountability could also have catastrophic consequences for critical infrastructure over time. As industries rush to embrace the latest technologies, the goal should always be responsible AI designed to support, rather than replace that all important human judgment.
Two words for you: sustainable automation.
My guest today is Arti Garg, chief technologist at AVEVA.
This podcast is produced in partnership with AVEVA.
Welcome, Arti.
Arti Garg: Thank you, Megan. It’s great to be here.
Megan: Thank you so much for joining us. And just to start, if we could set some context for our discussion, can you share a bit about the current state of industrial AI and what AVEVA is working on at the moment as well?
Arti: Yeah, more than happy to. And I want to go back to what you already stated, which is that in some ways, industrial AI is not new. It’s something that, even here at AVEVA, we’ve been working on for more than 20 years, really thinking about how AI can enhance applications in the industrial sector.
But what has changed quite substantially in maybe the last few years is the type of AI. We’ve really moved to these general purpose foundation models, which enable a lot more people to leverage advanced AI technologies. In addition to that, in just the last couple of years, there’s been an explosion in what’s known as physical AI and the types of AI that can really accelerate the capabilities of robotics and autonomous systems. And also agentic AI, which also allows for automation at more of the software level.
And what we’re seeing is that while in the past there has been some hesitancy to adopt models that don’t totally have predictable outcomes, there’s been a rapid acceleration in adoption of AI even in the industrial sector. One study suggests maybe that’s almost a 78% increase over the past just two years within the industrial sector. So yes, that’s an inflection point, but it’s almost like a step function if you think about it with respect to AI adoption.
And what we’re really thinking about now at AVEVA is, how do we think about this? How do we think about incorporating these new and very powerful AI technologies in environments where customers have mission-critical operations, human safety is a significant factor? Those are some of the primary concerns that our customers have when they think about adopting any new technology. We’re doing that in narrow where these newer types of AI aren’t necessarily predictable, in terms of how they behave. That’s one of the areas we’re really thinking about is, how do we leverage these technologies while maintaining safety, while maintaining reliable operations, while still being able to deliver on the promises of the new capabilities?
Megan: There’s so many things to consider at once, isn’t it? And you outlined there some of the huge developments we’ve seen in this space in recent years. What makes this such a pivotal moment for industrial AI specifically? What has changed to make some of those perhaps more out there hypotheticals much more plausible?
Arti: Well, I think one of the big things, one of the big challenges within industrial AI, and this is something that as AVEVA, it’s in our blood, it’s in our core DNA, is that to really leverage any kind of digital technology in the industrial space, one of the first important things you often need to do is gather and correlate data from disparate systems, so that maybe I have telemetry coming off of a pump or a mixer, and I want to be able to correlate that with service logs so I know maybe the last time that someone had done some maintenance on that pump or mixer. And maybe I also want to be able to correlate that with the original design documentation and some of the original documentation on how to maintain that, so that if something is happening, I can do a better job diagnosing what’s going wrong and how to address it. This has always been a core challenge in the industrial space.
I think that what’s happening now is that with newer technologies, even things like graph databases and being able to leverage AI to really match disparate data sets much faster, we’re able to get to the point where if something goes wrong, instead of an operator maybe needing to spend a little bit of time doing this research to really understand how do these different components fit together of information, they may have just an iPad with an AI that can very quickly go and fetch that information, correlate it and help in real time, almost, diagnose what is happening.
Even a little bit more out there, but not as out there as you might think is, I still describe this with a human operator with potentially a mobile tablet, but imagine now I can also have a robot moving through that environment also gathering data and either with onboard computation or a quick connection to an operator who doesn’t necessarily now have to go out into a dangerous, potentially somewhat hazardous space, be able to gather data and enable that very quick diagnostic as well. And I think that’s really what’s exciting right now and what all of these new technologies that I’ve talked about are helping to enable.
And I think then from our perspective, trying to really leverage all of those means that we have to think a lot now about our governance approach to this. How do we leverage AI in a way that keeps it contained, if you will?
Megan: Yeah, absolutely. And on that governance point, how does AVEVA define responsible AI and what do you see as the primary benefits?
Arti: Yeah, so I think for us, we think about a triple mandate around responsible AI, and that means that it’s secure, it’s efficient, and that includes environmentally efficient, and then it really preserves human safety and human oversight above all. And for us, that’s what some of our core pillars of responsible AI include. And for us, that means we think about internally as we build tools, a multi-layered governance approach where we’ve got both for how we use AI as a company and then how we deploy AI into our products. We’ve got a similar framework that we leverage across both, a kind of joint governance model, both around how we’re leveraging AI and also how we’re infusing AI into our products to allow our customers to leverage AI in their operations.
But I would say one of the core foundational principles underneath all of these is that human beings still remain centered in how we think about how AI is leveraged. And so human judgment, human responsibility, human ethics are still core to how we think about where AI can add benefits, and we think about it more as augmenting rather than replacing human beings in critical decision loops, if you will.
Megan: Right, which is such an important distinction, isn’t it? And in terms of the next phase of development, there’s growing sentiment that agentic AI will soon allow these industrial systems to operate much more autonomously. I wonder, what makes the risks in industrial settings different from AI risk in a purely digital context? And I suppose on the flip side, what are the benefits and opportunities of that same software defined automation?
Arti: I think we can start with the risks and then go to the benefits. I think ultimately, I would say the biggest risk in the industrial setting is that we are interacting with real physical systems, often physical systems that are very capable of delivering important outcomes that keep our world running, whether that’s delivering power, whether that’s mining for natural resources. But usually. Those physical systems are also operating in hazardous environments, the equipment itself is capable of also having human safety implications. Anytime you’re interfacing software with a physical system that can have real world consequences, you have to be extra careful. And we’ve always had that, again, we’ve had that in our DNA at AVEVA from the beginning, being mindful of that end user and that end application, which is not just something on a computer screen.
Even as we’ve deployed AI over the past few decades into our systems, we’ve typically leaned toward really trying to pick the best fit model, really understand that model’s behavior if we’re going to use, for example, we have a proprietary anomaly detection model that works in a lot of operational environments. Now, as we’re thinking about some of these newer AI capabilities, which by design are hard to understand how they behave, they’re not fundamentally explainable in the way we’ve thought about even AI or statistical models in the past, and actually their behavior can change over time as they learn and get tuned to new capabilities. That’s really the potential risk of automating a physical system based on capabilities that can evolve over time is one of the things that we have to be really mindful of and really thoughtful around, where are we willing to put some of that increased automation into practice?
But at the same time, I think there’s a real opportunity there, because I glossed over this idea that, okay, well, models evolve, but so do human beings, and sometimes that’s a good thing. We talk about humans having expertise and they gain understanding over their careers of how a system works. If we can actually leverage the ability of some of these newer AI capabilities, these sort of reasoning models often have underlying agentic capabilities, to learn and gather experience faster, and potentially even more importantly or more valuably, take experience that’s learned at one site and apply it to another site, then that’s a real opportunity to take what we already know works for human beings, which is that sometimes you just have to learn by doing and be able to apply that and scale that through AI. That’s where I see potentially a real opportunity in this space.
One of the things that we’re really aware of in the industrial sector is just the way that our workforce is changing. I think that almost half, not quite half, of the industrial workforce is set to retire in the next five years, and that’s a lot of expertise and experience that means that we’re going to lose in the sector. If there’s ways to make sure that we can capture that in ways that are actionable, in ways that can also help a newer generation of workers that are used to experience things in a different way, apply that expertise, apply that knowledge, then I think that’s a huge opportunity within the industrial space.
Megan: Yeah, absolutely. Clearly, some huge opportunities there particularly against the backdrop of other market and workforce changes as you’ve outlined there. I suppose building on that, what is the potential for these autonomous industrial AI systems when built and deployed responsibly to facilitate even faster, more sustainable industrial processes?
Arti: I think there’s a couple different ways to think about this. One is, what are the demands of potentially more environmentally sustainable processes? I’ll use one example of something that my team has been working on in partnership with Idaho National Laboratory here in the U.S. as part of their testing for AI grid resilience project.
One of the challenges in the electric grid as we’re moving toward a future where we have a lot more intermittent renewable power generation sources, often distributed rooftop solar for example, is it’s becoming much more challenging to manage the grid both from really understanding where electric capacity is coming in, electric load is pulling off of the grid. In addition to that, being able to maintain just power quality because instead of having one spinning asset delivering the frequency of electricity that’s going across the grid, you’ve got a lot of smaller systems. AI is actually quite critical for being able to manage that grid of the future. And this is one of the things that we’ve been working in partnership is, how can we do that? How can we help grid operators better understand what’s happening across their system, identify where things might be behaving anomalously so they can detect that early and then remediate for it?
At the same time though, I always talk about that’s an example of where AI can potentially help us accelerate the transition to a lower carbon energy future. At the same time, I think there’s a lot of conversation around the sustainability of AI itself. What are the power requirements? What are the resource requirements needed to run AI? And before I get into how do we think about that at AVEVA, because it is definitely something we think about and I think a lot of actors in the space are thinking about, I want to point out, is one of the challenges is that there’s really no agreed upon method to measure the environmental impact of AI. You see a lot of these stories, like one query on some kind of chat interface is X amount of gallons of water or this amount of electricity use. But the truth is that community-wide, there’s no agreed upon standard.
One of the things that I’m involved with is a standards working group that was launched by the IEEE two years ago, a little over two years ago. I’m the chair of that working group, it’s called the P7100 Standards Working Group on measuring the environmental impact of AI. And one of the things we’re trying to do is really identify all the different areas over which we want to think about environmental sustainability associated with AI, and then having one standard methodology that works and that can be adopted both from a reporting perspective and potentially also from an oversight or regulatory perspective. That becomes really important for any sort of real understanding of how AI impacts the environment is just we have to know, what does it use? We want to look holistically at that. Our standards cover electricity and energy consumption, it covers resource usage, it covers water consumption, and it also covers carbon.
But all of that said, I think it’s important for us to understand the footprint of AI, but I think it’s also important for us to simultaneously recognize that a bigger model uses more compute and more compute probably leverages more resources. The more that we can be intentional and pick the right size model for the right application, the more we can already start down that path of being more environmentally efficient in the AI that we run. One of the potentially nice side effects of that is the more purpose-built a model, the less likely it is to misbehave in unpredictable ways, if you choose correctly your architecture. There’s some sort of ancillary benefits that go beyond environmental sustainability.
Megan: Fascinating. It’s really, really interesting to hear some of the work going on behind the scenes there, because I think we’ll all have heard some of the statistics around the environmental impact, as you say. So, it’s great to understand some of the work going on there to really clarify that.
And we’ve talked a little bit about AI augmenting humans earlier. As systems gain greater autonomy, how should organizations think about that balance between closed loop automation, human in the loop accountability? What guardrails need to be in place? And how are governments and cross-border actors approaching those concerns as well?
Arti: There’s a lot packed into that question, so I’ll try to answer it somewhat one by one. First, starting with that sort of balance between closed loop and human in the loop, automation and accountability. One of the things that we talk about in the industrial sector is from human operator to human supervisor of systems, of industrial systems. And if I’m honest about that, we’re still trying to figure that out. When a human’s in a loop in an automated system, you’re really thinking about a system may process all the data and then make a recommendation.
We’ve got a solution that we’ve been working on more jointly with a few different customers where we’re able to take in a lot of their operational data, also some simulations of how their systems work, and be able to provide, say, recommendations around, you should now operate at this set point instead of that set point based on some of the other conditions that are changing in your plant. There’s a lot of interest in moving from having that be a recommended set point to have an automation that can automatically adjust the set point. And we’ve actually had some successful real-world pilots around that as well.
But when you get into that, obviously it makes people very nervous if you’re changing set points on industrial equipment. That’s where you maybe continue to have some guardrails around like, you can’t go outside of a certain band, for example, of operations, or we only allow the automation in certain areas. That’s where the human supervisor, the same way a human supervisor might give employees a lot of bandwidth or a lot of flexibility to make decisions around certain things, around other things, they’re hard and fast, like this is the deadline or this is the sort of production target. It’s like that. So thinking about, how do you put the appropriate guardrails?
The challenge is, AIs are not human beings, and so the guardrails look different, and I think that’s one of the things that there’s still to think about. That question of, what guardrails should be put in place? I think that it’s going to be probably dependent a little bit on the application, but over time I think we’re all going to learn, and so being really upfront and thoughtful about how we do this I think is important.
But the opportunity though, potentially, is really great. I’ve already mentioned that AI can be very useful in synthesizing a lot of information and bringing to the forefront, this is what matters. That’s something that we do want to create some space to experiment around, but what’s then important is making sure that a human being understands the risk.
I’ll give a little bit of a personal story because it might be illustrative. This weekend, I bought a little toy robot and decided I wanted to program it to do some stuff, and I found AI very, very helpful to get me started to read all the documentation. Putting the robot together was straightforward, they had nice instructions, but there’s a pretty heavy software developer kit that’s already there, but going through and reading all that documentation can take a while. AI was super helpful to help me surface, this is the function that does this, to help me get started. But occasionally, it made really bad recommendations on the best way to troubleshoot something.
That’s where I think having the human being in the loop, being able to say, “I know that it’s not going to be the best software architect or the best troubleshooter,” is really helpful because I had the opportunity to leverage AI for what it’s good for, synthesizing and surfacing a lot of information, but being able to say, “I don’t think that’s the most efficient first step. Let’s try something else.” That’s where it’s a really different way of working, but it’s something that I think as humans get more comfortable with the power and limitations of AI, you can start to teach people how to work with it, and it’s very different from how you would work with other digital tools.
One of the things that is important when it comes to AI is recognizing just the breadth of things that it touches and the breadth of impacts that it’s going to have, whether it’s on the environment, as we’ve discussed, whether it’s on productivity as sort of implicit in this entire discussion, whether it’s on labor force, whether it’s on just how economies work. From my eye, and I’m by no means a policy expert in this area, but from my eye, what I’m seeing is that different governments are prioritizing different aspects of that from how they’re thinking about regulatory and other kind of governance approaches.
Megan: We’re absolutely seeing some really vastly different approaches to this, aren’t we, around the world? I wondered to illustrate some of this, if you could share perhaps some case studies you’ve seen, maybe talking us through what lessons they could hold for other organizations perhaps a little earlier in their own AI journeys.
Arti: I think a lot of the key areas where we’re seeing very clear benefits of adopting AI in the industrial sector, the core to all of them is actually getting the data right and getting the right foundation of data so that you can build AI on top of it.
One of our customers, SCG Chemicals, which is a petrochemical company in Thailand, they had this vision of producing a reliability platform for their operations that was as AI-driven as possible. But a core part of that was actually getting the data right, being able to have all of their information in the right place, leveraging some of AVEVA’s tools to do that. Bringing together operational data and also engineering data. And then putting on top of that AI capabilities, in this case, one of our capabilities called AVEVA Predictive Analytics that deploys some proprietary models to do things like detect anomalies, so that they could really much earlier identify potential operational risks. And instead of having unplanned downtime, translate that to planned downtime. When you translate unplanned downtime to planned downtime, you can get a huge improvement in plant reliability.
At this point they’re targeting something like 99% plant reliability and a very, very high return on investment from the platform that they put in place. Again, in early pilot days, it was almost a 9x ROI, and so that’s really quite impressive. But what I want to emphasize is that it’s kind of a multi-layered problem to get it right.
Megan: Those are some really striking results, though. I mean, for industrial leaders who perhaps are still hesitant to explore AI, I wonder, what do you think is the cost of taking a more wait and see approach?
Arti: I think, again, this is an area where the industrial sector has a little bit of a different calculus to apply to this type of problem. In general, I think you would hear most business experts say that you can’t afford to take a wait and see approach to AI because it is so transformative across every sector of society and economy, and certainly in the industrial space, we’re not immune to that. But I do think that some of the challenges that I’ve outlined today also puts leaders in the industrial space into a mindset of sometimes potentially being a fast follower rather than the first adopter of newer technologies, just because the risk is so high.
But that being said, I think one of the challenges is that the risks that we’ve covered today around infusing systems that don’t always behave predictably with physical systems is that I don’t know that there’s a lot of other sectors that are going to be solving those problems. That’s where what I’m seeing is actually a lot of interest and excitement in trying new things and willingness to do that because there’s a recognition that applied correctly and applied with the right guardrails and safeguards in place, these technologies really have truly transformative potential from a resource usage standpoint, from a human safety standpoint, from a productivity standpoint.
I think the calculus has shifted a little bit in the sector to we want to actually try these things out. But then it becomes more, how do we try these things out in environments that we can make a little bit more sandboxed or safe to test out what some of the unique challenges we’re going to face in the industrial sector are?
Megan: Yeah, absolutely. It’s just hard to ignore the potential nowadays, isn’t it? And just to close with a slightly future forward look, I suppose, what are you most enthusiastic about in terms of the long-term potential of responsible autonomous industrial AI systems?
Arti: Yeah. Well, I think that there’s a couple of different trajectories. One of the things that I think within the next 18 months for sure, we’re going to see an increase of people with deep domain expertise who maybe didn’t grow up with a software background, be able to adopt AI assisted coding techniques to really be able to build the things that they weren’t able to build before.
That’s really exciting in my career, which way back when I was actually an industrial data scientist, I would say I always felt the most energized and that I learned the most talking to the people that were on the front lines of operations, having to monitor a lot of different equipment and understanding how it all worked together. They really have a lot of expertise, and being able to put in their hands the ability to very quickly develop new applications is I think going to really lead to a lot of new ideas that many of us in the industrial software space maybe wouldn’t even have thought about and really understood how to put. I think that’s really exciting.
I think then looking beyond that, I was a little bit of a, not to say a robotic skeptic, because clearly robotics and autonomous systems are going to be important, especially given the types of environments, whether they’re hazardous or remote, that industrial equipment operates in. But I just actually think things are moving a lot faster than I had anticipated. I’m really interested to see how these physical embodiments of AI systems start to really transform, again, how we think about operations.
One of the things about any new technology in any environment is that to really gain value from it, you have to change the way you do things. I would say for close to 10 years now, I’ve been giving talks on AI adoption and I always say the biggest barrier to AI adoption is not anything to do with the technology. It’s not even to do with the data, although data are often the biggest sticking point, it’s really to do with, are you going to change your business processes to be able to work with the way this technology is good or not good at things?
Autonomous systems, whether they’re robots or drones, are really going to change the way that we work in plants, in power systems, on mining sites. And I think that will make these types of operations more efficient, much safer for the human beings involved and more productive. So, I’m quite excited about that.
I don’t know entirely what direction it will go, but one of the things that I think about a lot is that if you go back to I, Robot and Isaac Asimov’s book, the premise of those was that robotics would be the first broadly adopted AI, not computer-based systems. We went in the other direction and I think it’s really interesting to now see all of this converging.
Megan: Yeah, absolutely. See robotics catches up a bit. So many exciting things on the horizon, that’s for sure. Thank you so much, for your time.
That was Arti Garg, chief technologist at AVEVA, whom I spoke with from Brighton in England.
That’s it for this episode of Business Lab. I’m your host, Megan Tatum. I’m a contributing editor at Insights, the custom publishing division of MIT Technology Review. We were founded in 1899 at the Massachusetts Institute of Technology, and you can find us in print, on the web, and at events each year around the world. For more information about us and the show, please check out our website at technologyreview.com.
This show is available wherever you get your podcasts. And if you enjoyed us, we hope you’ll take a moment to rate and review us. Business Lab is a production of MIT Technology Review, and this episode was produced by Giro Studios. Thank you so much for listening. Goodbye.
Learn more at aveva.com.
This content was produced by Insights, MIT Technology Review’s custom content arm, not its editorial staff. It was researched and written by humans, with any AI tools that may have been used limited to production processes under human oversight.
2026-10-07 20:10:00
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.
Popular weight-loss drugs may do more than help people shed pounds. They might also slow the aging process.
Drugmakers Eli Lilly and Novo Nordisk say patients taking their GLP-1 drugs age less quickly, according to molecular “aging clocks” that track changes in DNA or levels of key proteins.
The findings add to speculation that GLP-1 drugs could be acting on basic causes of aging and might be true longevity treatments. But how much can we read into these results?
Read the full story on what the new findings reveal about GLP-1 drugs and aging.
—Antonio Regalado
Energy Dome is one of MIT Technology Review’s10 Climate Tech Companies to Watch 2026, available exclusively to subscribers.
Solar and wind are among the cheapest and quickest ways to add electricity to the grid. But they’re subject to variations in weather patterns, so supplies can be intermittent. Energy Dome has an unusual solution: massive batteries that use compressed carbon dioxide to store energy for when the grid needs it.
Compressing gas to store energy isn’t new. Utilities have used compressed air in underground caverns to hang on to reserves for decades. But Energy Dome’s approach doesn’t require any specific geology to work, so it could be more easily scaled to help grids around the world.
Here’s how the company is using carbon dioxide to store renewable energy.
—Casey Crownhart
Subscribers can now access the full 10 Climate Tech Companies to Watch, spanning everything from mobile flood barriers and electric buses to next-generation nuclear reactors.
—Thore Graepel, a core member of DeepMind’s AlphaGo team
Ten years ago, I watched a program I helped build stun the world by beating Go champion Lee Sedol. AlphaGo won after making a move so strange that some commentators thought it was a programming glitch. It was AlphaGo’s powers of reasoning that made this creative choice—and these are powers that today’s AI lacks.
This is why I recently left my position at Google DeepMind. I believe we need a fresh approach to machine reasoning, one that draws on AlphaGo’s architecture.
This is our latest story to become an MIT Technology Review Narrated podcast, which we publish each week on Spotify and Apple Podcasts. Just navigate to MIT Technology Review Narrated on either platform, and follow us to get all our new content as it’s released.
The must-reads
I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.
1 OpenAI has released 377 new math findings, further rattling the field
They span number theory, algebra, geometry, and physics. (NYT $)
+ They came from testing an unreleased OpenAI model. (Verge)
+ And cost far less than its previous math breakthroughs. (SciAm)
+ OpenAI also published a lengthy defense of its approach. (Gizmodo)
+ AI has put mathematics at a crossroads. (MIT Technology Review)
2 Mistral says its new open-weight model is the best outside China
Mistral Large 4 is a 1-trillion-parameter model. (Reuters $)
+ Also known as le Chonk, its weights will arrive on October 27. (CNBC)
+ French president Macron described it as “a third way in AI.” (TechCrunch)
3 Finland has ordered Google to halt a record data center project
The order follows concerns over environmental impacts. (Guardian)
+ The €13 billion project is Google’s largest-ever European investment. (BBC)
+ But no one wants a data center in their backyard. (MIT Technology Review)
4 The EU plans to tax Big Tech through a new corporate levy
The levy would apply to companies earning more than €100 million. (FT $)
+ Tesla is pushing the EU toward “Full Self-Driving” approval. (Reuters $)
5 Anduril’s $2.9 billion Navy submarine deal has sparked ethics concerns
Co-founder Palmer Luckey recently joined a new Pentagon project. (CNBC)
+ Anduril is also making smart glasses for warfare. (MIT Technology Review)
6 Apple is partnering with LG on a smart lock, thermostat, and doorbell
Apple’s new smart-home hub is expected to launch next week. (Bloomberg $)
+ The companies are also co-developing security cameras. (TechCrunch)
7 The creator of a space-particle observatory has won the physics Nobel
Francis Halzen used Antarctic ice to detect elusive neutrinos. (New Scientist $)
8 Drones are being used to make rain on demand
They seed clouds with silver iodide to encourage precipitation. (BBC)
+ A startup claims it can stop lightning. (MIT Technology Review)
9 A new hydrogel could enable shape-shifting smart devices
The material can evolve alongside living tissue. (SCMP)
10 You probably aren’t going to get the plague
Experts say the risk to the public remains very low. (Wired $)
Quote of the day
—Mike Tyran, a 66-year-old nurse and tech upgrade holdout, tells The Atlantic why he won’t swap his old gadgets for the latest AI-powered devices.
One more thing
Human-made glass is thousands of years old. But it’s now poised to find its way into the AI chips used in the world’s newest and largest data centers.
This year, a South Korean company called Absolics will start producing special glass panels that make next-generation computing hardware more powerful and efficient. Other companies, including Intel, are also pushing forward in this area.
If all goes well, the technology could reduce the energy demands of chips in AI data centers—and even consumer laptops and mobile devices. Read the full story.
—Jeremy Hsu
We can still have nice things
A place for comfort, fun, and distraction to brighten up your day. (Got any ideas? Drop me a line.)
+ Swiss boffins have turned train tracks into solar power plants.
+ Here’s an intriguing explanation of why you can see a clear image through a window.
+ A teen with a rare genetic disorder has walked for the first time after receiving an experimental medicine.
+ Stunning shots of guillemots, penguins, and a protective tawny frogmouth contended for prizes at the Bird Photographer of the Year competition.
2026-10-07 00:40:36
Popular weight-loss drugs may do more than help people shed pounds. They might also melt away the years.
Drug giants Eli Lilly and Novo Nordisk say patients taking their drugs age less quickly, according to readouts from molecular “aging clocks.”
Such clocks assess a person’s biological age by looking at changes to DNA that accumulate with time, or, in newer versions, by tracking levels of key proteins.
Both companies found that overweight or diabetic patients taking the drugs, called GLP-1s, had reduced biological age compared to those taking a placebo, although the difference varied widely, depending on which type of clock was used, and what organ was tested.
Overall, the difference was around “two to three years,” according to Nikolaj Roed, a global project leader at Novo, who says the company has been seeing “improved biological age in our patients across trials and across different tissues.”
The findings add to wide speculation among scientists that GLP-1 drugs, as they are known, are acting on basic causes of aging and might be a true longevity treatment.
“Two years is a pretty strong effect, in my book,” says Steve Horvath, a professor at the University of California, Los Angeles, who’s credited with inventing aging clocks. Horvath says the emerging data could provide “evidence that these GLP-1 drugs are actually what is known as geroprotectors, medications that slow or possibly even reverse biologic aging.”
The companies shared their findings over the weekend during Aging Research & Drug Discovery, a conference devoted to seeking scientific remedies for old age. While that quest has not yet produced any clear-cut success, some scientists now think Novo’s drug semaglutide (sold under the names Ozempic and Wegovy) is coming close.
“In an unhealthy population, I do think it’s an anti-aging drug,” says Vadim Gladyshev, a Harvard biologist who assisted Novo with its molecular measurements. “But in a healthy population, no one knows.”
The drugs cause weight loss by stimulating a receptor, GLP-1, that tells your brain you’re not hungry. Yet real-world studies have shown much wider benefit. The drugs improve kidney function, reduce blood pressure, and even sharply cut the overall chance of death.
“If the question is,‘Can semaglutide reach several diseases relevant to health span and aging?’ we know we can say the answer is yes,” said Alejandro Aguayo-Orozco, a senior scientific director at Novo, the Danish drug giant, during the meeting.
The next question to answer, he said, is whether such effects are accompanied by changes to molecular measures of biological aging: “When you intervene with semaglutide, does it actually move the clocks in any direction? And the answer is yes.”
The company found that, over time, the drugs cause a wide slowdown in aging clocks—as much as 4 years in the case of a clock that looks at heart proteins. “I think it’s pretty clear that the organ age is shifting,” said Aguayo-Orozco.
The studies are also a huge boost for the science of aging clocks. Although these measures reflect a person’s age, it’s been uncertain if they are useful as true biomarkers. Now clock makers have evidence that their readouts show a drop in age when people take drugs with broad, well-demonstrated benefits.
“The clock people have been pushing for a decade to get this kind of study done,” says Yuge Ji, a biologist who previously worked in the field and now runs a startup, Reflector Bio. “It’s huge for them.”
As part of its study, Novo took blood draws from 10,052 people, half on the drug and half on a placebo. Their blood, collected at the start of the study as well as months later, was then measured with “proteomic clocks,” which use levels of key proteins to predict a person’s age and risk of dying.
Scientists at Eli Lilly performed similar research on their GLP-1 drug, tirzepatide, using so-called “epigenetic” clocks that assess age by counting accumulated changes to DNA. Lilly’s study was smaller, but also found that for the most part, molecular time moved more slowly for people on the drug.
“All the clocks are telling a consistent story that we’re seeing a reduction in age,” Kevin Duffin, vice president for aging research at Lilly, said during the conference. “It’s not like we’re going to reverse age by 30 years or something, but it’s a significant reduction.”
The molecules have become the best selling drugs in the world,, with Lilly’s tirzepatide, sold as Mounjaro for diabetes and Zepbound for obesity, topping the list with more than $36 billion in revenue to the company last year. Novo’s semaglutide, also sold under more than one name, was a close second.
Alex Zhavoronkov, the founder of Insilico Medicine, and the organizer of the Boston meeting, says that extending lives by even one year across the world’s population would be equal to tens of millions of lifetimes.
Last month Zhavoronkov showed that one of his company’s drugs, for a lung disease, also reversed the signals from aging clocks. That drug is experimental, but Zhavoronkov has sought to promote the idea that humanity is entering a new era of longevity medicines. He also disclosed during the event that he has been “microdosing” the available weight-loss drugs, even though he is not overweight.
“I am on tirzepatide and I am an equal-opportunity injector of semaglutide as well,” Zhavoronkov said.
It was part of an effort to directly raise the question of whether the first mass-market anti-aging remedy is already here.
“Do you think a reasonable person should start taking semaglutide?” he asked Aguayo-Orozco, the Novo scientist, in front of a crowded audience.
“I am not a physician. I cannot answer that question,” Aguayo-Orozco replied.
Several people cautioned that GLP-1 drugs do have side effects, including muscle loss. That is one reason they might not help most people, says Horvath, who says he isn’t ready to take the drugs himself, although he’s thought about it.
“Clearly, the drugs have many benefits in obese people, but I did not yet see sufficient evidence that they will benefit skinny people,” he said. “I guess we will have to wait.”
Answers could start to emerge in a year or two. This past January, a US agency, ARPA-H, put $38 million toward a study in Texas that will attempt to determine whether semaglutide has anti-aging effects in healthy people over 60. That research will look at changes in cognition, mobility, and acuity of the senses.
That project also seeks to help define a regulatory pathway for anti-aging drugs and to “build a new therapeutic industry” around longevity.
2026-10-06 20:10:00
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.
Each year, MIT Technology Review puts together a list of the most promising climate tech companies in the world. This year, the stakes feel higher than ever. The world is on track for one of its hottest years on record, climate-fueled disasters are taking lives and costing billions, while political shifts and international conflict have stalled progress.
We urgently need to cut emissions and avoid climate change’s most harmful effects, and that’s where our 10 companies come in.
They’re working on everything from mobile flood barriers and semi-solid-state batteries to compressed-CO₂ energy storage and next-generation nuclear reactors. They also reflect the biggest shifts in climate tech—including the surging energy demands of AI data centers.
Meet the 10 companies working on some of the biggest challenges in climate tech.
Over the coming days, we’ll take a closer look at each of the 10 companies, along with how we chose this year’s list, right here in The Download. So stay tuned!
The must-reads
I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.
1 Musk’s new Pentagon role has raised conflict-of-interest fears
His companies could directly benefit from the weapons he recommends. (NPR)
+ SpaceX has received billions in Pentagon and NASA contracts. (NYT $)
+ Beware the rise of the “Pentagon-Silicon Complex.” (Gizmodo)
+ The Pentagon wants an AI-powered lie detector. (MIT Technology Review)
2 The only billionaires making money this year are in tech
Tech fortunes now account for 36% of billionaire wealth. (Bloomberg $)
+ Nvidia is on the verge of the first $6 trillion valuation. (CNBC)
+ SpaceX stock has made Elon Musk a trillionaire again. (Gizmodo)
3 Norway is planning the first national ban on smart glasses
Camera-enabled glasses could be barred from public spaces. (Guardian)
+ Several other countries are also mulling bans. (Reuters $)
+ Smart glasses are causing havoc in India. (MIT Technology Review)
4 Tandem panels could help the US catch up with China in solar
They could produce 25% more electricity from sunlight. (NYT $)
+ The balcony solar boom is coming to the US. (MIT Technology Review)
5 South Korea’s President suspects AI’s been used in bank hacks
He called for new cybersecurity measures for the AI era. (Reuters $)
+ OpenAI agents may have caused a Wikimedia outage. (Verge)
+ Who’s liable when AI agents go rogue? (MIT Technology Review)
6 Russian drones are exploiting air defense gaps to hit data centers
The attacks are disrupting Ukraine’s digital infrastructure. (Ars Technica)
7 The AI boom is killing the world’s cheapest smartphones
Memory costs are squeezing out affordable phones. (Rest of World)
8 Pioneers of light-based brain mapping have won a Nobel prize
Their technique shines new light on brain circuits. (BBC)
9 AI slop has pushed arXiv to limit preprint research submissions
Submissions have doubled in two years. (404 Media)
10 McDonald’s is being sued over AI-powered Big Mac pricing
The lawsuit alleges AI helped franchises coordinate prices. (Reuters $)
Quote of the day
—AI researcher Jacob Coxon, who resigned from Anthropic over fears that it’s building systems that it won’t be able to control, tells New York Magazine his views on the company’s culture.
One more thing
Much of the spotlight on AI in the Iran conflict has focused on models like Claude helping the US military decide where to strike. But a wave of “vibe-coded” intelligence dashboards—and the ecosystem surrounding them—reflect a new role that AI is playing in wartime: mediating information, often for the worse.
These sorts of intelligence tools have much promise. Yet there are real reasons to be suspicious of their data feeds. Read the full story.
—James O’Donnell
We can still have nice things
A place for comfort, fun, and distraction to brighten up your day. (Got any ideas? Drop me a line.)
+ A forgotten forest experiment reveals a “win-win-win” for trees 30 years later.
+ A gym-rat bear and a scowling owl star in this showcase of the year’s funniest wildlife photos.
+ Some fast-food chains have vanished, but these eight nostalgic names are still serving up beloved junk.
+ Find out what happens when you put a grown man inside a giant water balloon and roll him down a ramp.
